Art as we know it today could not exist had not the revolutionary work of the Renaissance artists paved the way. Widely considered the most important and influential movement in the history of fine arts, literature, architecture, and science, the Renaissance marked the emergence of Western civilization from the Middle Ages into the modern era. Beginning in the 14th century in Italy, the movement spread throughout Europe by the late 15th century, the main centers of fine art activity being in Florence, the Low Countries, and Germany. For the first time, art became intellectual; influenced by humanism, artists experimented with secular subjects and revived classical antiquity. Advances in anatomy and geometry produced more realistic depictions in terms of space and perspective for the Italians, while new oil painting techniques made their mark in Flemish painting and woodcuts and engravings were the specialties of the Germans. Artists featured: Albrecht Altdorfer, Fra Angelico, Giovanni Bellini, Hieronymus Bosch, Sandro Botticelli, Pieter Breughel, Agnolo Bronzino, Vittore Carpaccio, Francois Clouet, Correggio, Lucas Cranach the Elder, Albrecht Durer, El Greco, School of Fontainebleau, Piero della Francesca, Domenico Ghirlandaio, Giorgione, Matthias Grunewald, Maerten van Heemskerck, Hans Holbein the Younger, Fra Filippo Lippi, Lorenzo Lotto, Andrea Mantegna, Masaccio, Antonello da Messina, Michelangelo, Parmigianino, Pontormo, Raphael, Luca Signorelli, Tintoretto, Titian, Paolo Uccello, Veronese, Leonardo da Vinci.