Contents: DNA, Darwin, and the appearance of design -- The evolution of a mystery and why it matters -- The double helix -- Signature in the cell -- The molecular labyrinth -- The origin of science and the possibility of design -- Of clues to causes -- Chance elimination and pattern recognition -- Ends and odds -- Beyond the reach of chance -- Self-organization and biochemical predestination -- Thinking outside the bonds -- Chance and necessity, or, The cat in the hat comes back -- The RNA world -- The best explanation -- Another road to Rome -- But does it explain? -- But is it science? -- Sauce for the goose -- Why it matters.